CDK7-IN-26
CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.
Product Specifications
CAS Number
3024545-79-4
Field of Research
Cell Biology, Epigenetics & Chromatin
Smiles
N (C1=NC (=C2C (=N1) C=CS2) C=3C=4C (NC3) =C (P (C) (C) =O) C (C#N) =CC4) [C@H]5C[C@H] (F) CNC5
Molecular Formula
C22H22FN6OPS
Molecular Weight
468.49
Storage Conditions
-20°C
Notes
For research use only.
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