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CDK7-IN-26

CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.

Product Specifications

CAS Number

3024545-79-4

Field of Research

Cell Biology, Epigenetics & Chromatin

Smiles

N (C1=NC (=C2C (=N1) C=CS2) C=3C=4C (NC3) =C (P (C) (C) =O) C (C#N) =CC4) [C@H]5C[C@H] (F) CNC5

Molecular Formula

C22H22FN6OPS

Molecular Weight

468.49

Storage Conditions

-20°C

Notes

For research use only.

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