TrxR-IN-6

TrxR-IN-6 (compound 1d) is an inhibitor of TrxR that can induce the accumulation of reactive oxygen species (ROS) and possesses anticancer properties. This compound can further lead to the collapse of the redox system, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Ultimately, it triggers oxidative stress and induces apoptosis.