EGFR/c-Met-IN-1
EGFR/c-Met-IN-1 (compound TS-41) is a dual inhibitor targeting EGFR and c-Met, with IC50 values of 68.1 nM for EGFRL858R and 0.26 nM for c-Met. EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, and reduces phosphorylation of EGFR, c-Met, and downstream AKT. This compound effectively inhibits tumor growth both in vitro and in vivo.
Product Specifications
CAS Number
3020728-68-8
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C (C=C) NC1=CC=2C (=NC=NC2C=C1OC) OC3=CC=C (C=C3F) NC (=O) C=4C (=O) N (C=5C=CC=CC5) N (C4C) C
Molecular Formula
C30H25FN6O5
Molecular Weight
568.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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