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Type II TRK inhibitor 2

Type II TRK inhibitor 2 (compound 40l) is a selective Type II TRK inhibitor characterized by plasma stability and moderate liver microsome stability. It significantly impedes the proliferation of Km-12, Ba/F3-TRKAG595R, and Ba/F3-TRKAG667C cells with IC50 values of 4.1 nM, 41.5 nM, and 1.4 nM, respectively. Type II TRK inhibitor 2 is applicable for research into NTRK fusion cancers.

Product Specifications

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Molecular Formula

C30H27F2N9O

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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