Type II TRK inhibitor 2
Type II TRK inhibitor 2 (compound 40l) is a selective Type II TRK inhibitor characterized by plasma stability and moderate liver microsome stability. It significantly impedes the proliferation of Km-12, Ba/F3-TRKAG595R, and Ba/F3-TRKAG667C cells with IC50 values of 4.1 nM, 41.5 nM, and 1.4 nM, respectively. Type II TRK inhibitor 2 is applicable for research into NTRK fusion cancers.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C30H27F2N9O
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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