PVD-06
PVD-06 is a selective PROTAC-based degrader of PTPN2 (with a selectivity index of greater than 60-fold over PTP1B) and exhibits anticancer activity. It induces the degradation of PTPN2 through ubiquitination and proteasome-dependent pathways. PVD-06 also enhances T cell activation and amplifies IFN-γ-mediated cytotoxicity.
Product Specifications
CAS Number
3032975-48-4
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
C (C (O) =O) (F) (F) F.FC=1C2=C (C=C (O) C1N3S (=O) (=O) NC (=O) C3) C=CC (=C2) C4=CN (CC (NCCCCCC (N[C@H] (C (=O) N5[C@H] (C (N[C@@H] (C) C6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@@H] (O) C5) [C@] (C) (C) C) =O) =O) N=C4
Molecular Formula
C48H55F4N9O11S2
Molecular Weight
1074.13
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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