N- (Propargyl-PEG4-carbonyl) -N-bis (PEG1-methyl ester)

N- (Propargyl-PEG4-carbonyl) -N-bis (PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Propargyl-PEG4-carbonyl) -N-bis (PEG1-methyl ester) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2112732-01-9]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-propargyl-peg4-carbonyl-n-bis-peg1-methyl-ester.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

C#CCOCCOCCOCCOCCC(N(CCOCCC(OC)=O)CCOCCC(OC)=O)=O

Molecular Formula

C24H41NO11

Molecular Weight

519.58

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562