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WP9QY (TFA)

WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

Product Specifications

UNSPSC

12352209

Target

TNF Receptor

Type

Peptides

Related Pathways

Apoptosis

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/wp9qy-tfa.html

Purity

99.44

Solubility

DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CC(C=C2)=CC=C2O)=O)CCC(N)=O)=O)CO)[C@@H](NC([C@H](CSSC[C@H](NC([C@@H]1CC(C)C)=O)C(N[C@H](C(O)=O)CC(C=C3)=CC=C3O)=O)NC([C@@H](N)CC(C=C4)=CC=C4O)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O

Molecular Formula

C60H72F3N11O17S2

Molecular Weight

1340.40

References & Citations

[1]Lin CC, et al. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009 Oct;30 (28) :4907-14.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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