Goat Human antithrombin III Antibody

Antithrombin II is a single polypeptide chain glycoprotein (MW 61,000) with a high degree of homology with the alpha-1 antitrypsin. It is a circulating natural anticoagulant acting as a proteinase inhibitor. It is synthesized in the liver and the vascular endothelial cells. In electrophoresis of plasma it migrates in the alpha-1 region and is consumed during coagulation in vivo. Antithrombin III inhibits the action of factors IXa, Xa, XIIa, thombin and kallikrein by forming a stable complex. Heparin acts as a cofactor which greatly increases its inhibitory activities. Normal adult plasma contain an average of 0.15 mg antithrombin III per ml. This can vary from 75 to 128%. A partial deficiency in antithrombin III activity in the plasma (less than 50%) will result in an increased tendency to recurrent thrombo-enbolism. Several types of congenital deficiency have been reported. Most common type 1 deficiency patients have reduced antithrombin III antigen and activity levels. Heterozygotes have levels of 25 to 50% of normal values. For use as an immunogen antithrombin III is isolated and highly purified from pooled plasma. Freund’s complete adjuvant is used in the first step of the immunization procedure.

Delipidated, heat inactivated, lyophilized, stable whole antiserum No preservative added. Total protein and IgG concentrations in the antiserum are comparable to those of pooled normal goat serum. No foreign proteins added.