Tricaprilin

Tricaprilin (Trioctanoin) is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD) . Tricaprilin is a pure C8 medium chain triglyceride (MCT) [1][2][3].

Product Specifications

CAS Number

[538-23-8]

Product Name Alternative

Trioctanoin; Glyceryl trioctanoate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tricaprilin.html

Purity

98.0

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

CCCCCCCC(OCC(OC(CCCCCCC)=O)COC(CCCCCCC)=O)=O

Molecular Formula

C27H50O6

Molecular Weight

470.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Chow L, et al. Metabolic Mechanism in Migraine: Tricaprilin, a Ketogenic Agent[J].|[2]Walker J A, et al. Development of tricaprilin, a ketogenic drug for Alzheimer's disease[J].|[3]Walker J A, et al. Clinical development of tricaprilin, a ketogenic drug for Alzheimer's disease: Human/Human trials: Other[J]. Alzheimer's & Dementia, 2020, 16: e038787.|[4]Woodruff, M., et al. Immunogenicity, macrophage sensitivity, and therapeutic response to C. parvum of fibrosarcomas induced in C. parvum-treated and untreated mice. Cancer Immunol Immunother 12, 255-258 (1982) .