JNK-IN-7
JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively.
Product Specifications
CAS Number
1408064-71-0
Product Name Alternative
JNK inhibitor
UNSPSC
12352005
Hazard Statement
H302
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jnk-in-7.html
Purity
98.17
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(NC(/C=C/CN(C)C)=O)=CC=C1)NC(C=C2)=CC=C2NC3=NC=CC(C4=CN=CC=C4)=N3
Molecular Formula
C28H27N7O2
Molecular Weight
493.56
Precautions
H302
References & Citations
[1]Zhang T, et al. Discovery of Potent and Selective Covalent Inhibitors of JNK. Chem Biol. 2012 Jan 27;19 (1) :140-54.|[2]Wu W, et al. Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease. Sci Rep. 2015 Nov 17;5:16344.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3
Available Sizes
Frequently Asked Questions
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