JNK-IN-7

JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively.

Product Specifications

CAS Number

[1408064-71-0]

Product Name Alternative

JNK inhibitor

UNSPSC

12352005

Hazard Statement

H302

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jnk-in-7.html

Purity

98.17

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(NC(/C=C/CN(C)C)=O)=CC=C1)NC(C=C2)=CC=C2NC3=NC=CC(C4=CN=CC=C4)=N3

Molecular Formula

C28H27N7O2

Molecular Weight

493.56

Precautions

H302

References & Citations

[1]Zhang T, et al. Discovery of Potent and Selective Covalent Inhibitors of JNK. Chem Biol. 2012 Jan 27;19 (1) :140-54.|[2]Wu W, et al. Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease. Sci Rep. 2015 Nov 17;5:16344.