GSK2245035
GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN) -stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma[1].
Product Specifications
CAS Number
[1207629-49-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H361
Target
IFNAR; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk2245035.html
Purity
99.79
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(N=C(N=C2N1CCCCCN3CCCCC3)O[C@H](CCC)C)N
Molecular Formula
C20H34N6O2
Molecular Weight
390.52
Precautions
H302, H315, H319, H335, H361
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
TLR7; TNFRSF5/CD40
Available Sizes
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