GPS167
GPS167 is a specific small-molecule splicing regulator and SRSF10 inhibitor that modulates BCLAF1 alternative splicing with an IC50 of 2 μM in human colorectal HCT116 cells, while also directly inhibiting CLK1, CLK2, and CLK4 but not SRPK1 or DYRK1A, positioning it as a mechanistically well-defined probe for studying spliceosome regulation and kinase-dependent RNA processing.
Product Specifications
CAS Number
3034312-19-8
Purity
99.13% (May vary between batches)
Smiles
O=C (NC=1C=CC=2NN=CC2C1) C=3N=C (SC3) NC=4C=CC=CC4
Molecular Formula
C17H13N5OS
Molecular Weight
335.38
Storage Conditions
-20°C
Notes
For research use only.
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