AS2795440
AS2795440 is a PIKfyve inhibitor. It selectively suppresses the production of pro-inflammatory cytokines such as IL-12p40 and IL-6 and the activation of B cells, without affecting Ca2+ signaling. In a mouse model of adjuvant-induced arthritis (AIA), AS2795440 significantly reduces joint inflammation and bone loss. This compound is useful for researching inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Product Specifications
CAS Number
2171506-45-7
Field of Research
Immunology & Inflammation, Signal Transduction
Smiles
O=C (NC=1C=C (C=NC1C) C=2C=NC (=CC2) C3=CCN (CC3) C (C) C) C4=NC5=C (C=C4) NC (=C5C) C
Molecular Formula
C29H32N6O
Molecular Weight
480.60
Storage Conditions
-20°C
Notes
For research use only.
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