PROTAC SGK3 degrader-2
PROTACSGK3degrader-2 is the cis-diastereomer of PROTACSGK3degrader-1 (SGK3-PROTAC1), featuring a cis-hydroxy group in its VH032 section, which prevents binding to the VHL E3 ligase. This compound inhibits SGK3, SGK1, and S6K1 with IC50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but does not degrade SGK3. It serves as a control compound for studying the specific degradation effects mediated by SGK3-PROTAC1.
Product Specifications
CAS Number
2381196-78-5
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C[C@H]1CN (CCCCCCOCCOCCOCC (N[C@H] (C (=O) N2[C@H] (C (NCC3=CC=C (C=C3) C4=C (C) N=CS4) =O) C[C@H] (O) C2) C (C) (C) C) =O) CCO1) C=5N=C (N=C6C5C=NN6) C7=CC=C (NS (=O) (=O) C8=C (F) C=CC (C) =C8) C=C7
Molecular Formula
C57H73FN10O11S2
Molecular Weight
1157.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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