NVP-BQS481
NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs) .
Product Specifications
CAS Number
1161925-41-2
Field of Research
Signal Transduction
Smiles
[C@@H] (N (CC[C@@H] (CF) N) C (CO) =O) (C (C) (C) C) C=1N (CC2=CC=CC=C2) C=C (N1) C3=C (F) C=CC (F) =C3
Molecular Formula
C27H33F3N4O2
Molecular Weight
502.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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