PROTAC sEH-degrader-3
PROTACsEH-degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that selectively degrades cytosolic sEH without affecting sEH in peroxisomes. It degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasomal pathway, with an IC50 of 0.8 nM for hsEH. Additionally, PROTACsEH-degrader-3 inhibits endoplasmic reticulum stress, making it useful for research on diseases related to inflammation, metabolic disorders, and other conditions associated with endoplasmic reticulum stress.
Product Specifications
CAS Number
3093413-94-3
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2OCC (NCCOCCOCCOCCOCCNC (=O) C4=CC=C (O[C@H]5CC[C@H] (NC (NC6=CC=C (OC (F) (F) F) C=C6) =O) CC5) C=C4) =O
Molecular Formula
C46H53F3N6O14
Molecular Weight
970.94
Storage Conditions
-20°C
Notes
For research use only.
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