GPX4-IN-18
GPX4-IN-18 (Compound 17) is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4), and it also acts as a ferroptosis inducer. It enhances the production of reactive oxygen species (ROS) and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal carcinoma cells. In HT-1080 cells, GPX4-IN-18 induces ferroptosis with IC50 values of 0.007 μM (without iron inhibitor-1) and 1.486 μM (with iron inhibitor-1) . Additionally, GPX4-IN-18 reduces tumor volume and intratumoral GPX4 levels in an OS-RC-2 xenograft mouse model.
Product Specifications
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery
Storage Conditions
-20°C
Notes
For research use only.
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