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LYA914

LYA914 is an orally active AR/AR-V7 PROTAC degrader. It targets the proteolysis of the androgen receptor's (AR) conserved DNA-binding domain (DBD) . LYA914 demonstrates effective antiproliferative activity in Enzalutamide-insensitive or resistant cells and inhibits tumor growth in VCaP/LNCaP tumor mouse models. It is suitable for studying castration-resistant prostate cancer (CRPC) .

Product Specifications

Field of Research

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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