JWJ-01-378
JWJ-01-378 is a selective TRK PROTAC degrader. It effectively degrades wild-type TRK and TPM3-TRKA fusion proteins while inhibiting downstream pERK signaling, but shows limited degradation effects on TRK inhibitor-resistant mutants and ALK fusion proteins. Additionally, JWJ-01-378 effectively suppresses cancer cell proliferation.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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