Tuspetinib dihydrochloride
Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis) .
Product Specifications
CAS Number
3037216-20-6
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
ClC1=CN=C (NC2=CC (C3CC3) =CC (CN4C[C@H] (N[C@H] (C4) C) C) =C2) N=C1C5=CNC6=CC (C) =CC=C56.Cl.Cl
Molecular Formula
C29H35Cl3N6
Molecular Weight
573.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC741119-500 1x 500 µL
TGFalpha (TGFA/1119), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
![MHC Class II I-Ed Mouse Monoclonal Antibody [Clone ID: 34-1-4S]](https://cdn.genprice.uk/products/937/68dd18bc061270361e90932c/imageurl/cl073.webp)
CL073 1 mL
MHC Class II I-Ed Mouse Monoclonal Antibody [Clone ID: 34-1-4S]
Sign In for Pricing
View Details