VVD-849
VVD-849 is a RAS ligand that covalently binds to cysteine at position 242 within the RAS binding domain of PI3Kp110α, enhancing RAS/PI3K interaction. It partially inhibits pAKT (S473) in tumors overexpressing HER2. VVD-849 is applicable in cancer research, including studies on breast cancer.
Product Specifications
CAS Number
3055321-14-4
Field of Research
Signal Transduction
Smiles
S (=O) (=O) (C1=C (C=C (Cl) C=C1) C2=CC (OCC3=CC=CC=N3) =CC=C2) N4CCC (C (N[C@H] (/C=C\S (C) (=O) =O) C) =O) (F) CC4
Molecular Formula
C29H31ClFN3O6S2
Molecular Weight
636.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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