5α-Tetrahydrocorticosterone
5α-Tetrahydrocorticosterone (5α-HB) is an endogenous steroid that acts as an agonist of the glucocorticoid receptor (GR) and a metabolite of corticosterone. It serves as an effective topical anti-inflammatory agent in vivo. In rat liver cells, it decreases the binding of metabolites to the glucocorticoid receptor-corticosterone and its 5α-reduced metabolites, with a Kd value of 268 nM. 5α-Tetrahydrocorticosterone is applicable in research on inflammatory skin diseases.
Product Specifications
CAS Number
600-63-5
Field of Research
Metabolism Research
Smiles
C[C@@]12[C@@]3 ([C@] ([C@]4 ([C@] (C) (C[C@@H]3O) [C@@H] (C (CO) =O) CC4) [H]) (CC[C@]1 (C[C@H] (O) CC2) [H]) [H]) [H]
Molecular Formula
C21H34O4
Molecular Weight
350.49
Storage Conditions
-20°C
Notes
For research use only.
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