MP1202
MP1202 is a dual agonist for MOR and KOR, with EC50 values of 0.32 μM for mMOR-1 and 0.13 μM for mKOR-1. It exhibits functional selectivity by reducing β-arrestin1/2 recruitment in hMOR and hKOR while significantly activating G protein and Gα subtypes. In opioid receptor subtype knockout mouse models, MP1202 demonstrates potent antinociceptive effects without typical opioid side effects, albeit it induces conditioned place preference and aversion behaviors, indicating potential for analgesic research.
Product Specifications
CAS Number
2578974-82-8
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Smiles
N (C (=O) C1=CC (I) =CC=C1) [C@H]2[C@]3 ([C@]45C=6C (O3) =C (O) C=CC6C[C@] ([C@@]4 (CC2) [H]) (N (CC7CC7) CC5) [H]) [H]
Molecular Formula
C27H29IN2O3
Molecular Weight
556.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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