PI3Kα-IN-26

PI3Kα-IN-26 (Compound 11e) is a PI3Kα inhibitor with an IC50 of 75.31 nM. It demonstrates broad-spectrum anticancer activity, being effective against leukemia, colon cancer, and breast cancer, while exhibiting no significant cytotoxicity to normal Vero cells (average IC50 values are 2.74, 3.50, 3.34, and 85.29 μM, respectively) .