KWZY-11
KWZY-11 (Compound 11) is a potent dual inhibitor of PARP/CDK6, exhibiting IC50 values of 156.8 nM, 197.3 nM, and 13.3 nM for PARP1, PARP2, and CDK6 respectively. It suppresses tumor cell proliferation by modulating the Wnt/β-catenin signaling pathway. Additionally, KWZY-11 induces excessive DNA damage and apoptosis in MDA-MB-231 breast cancer cells.
Product Specifications
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.
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