PROTAC pan-KRAS degrader-1
PROTACpan-KRAS degrader-1 is a pan-KRAS PROTAC degrader that targets multiple KRAS mutants, including G12D, G12C, G12V, and G13D. It effectively degrades the KRAS mutant (G12D) in AGS cells, with a DC50 of 1.1 nM and a Dmax of 95%. This compound can be used in studies of diseases caused by KRAS mutations or amplifications, particularly in cancers such as breast, bladder, and gastric cancer.
Product Specifications
CAS Number
3043908-63-7
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (C1 (COC=2N=C (C3=C (N2) C (F) =C (N=C3) C=4C5=C (C=C (O) C4) C=CC (F) =C5CC) N6C[C@] (C) (O) CCC6) CC1) N7CCC (OC=8C=NC (=CN8) C9=CN ([C@H] (C (=O) N%10[C@H] (C (N[C@@H] (C) C%11=CC=C (C=C%11) C%12=C (C) N=CS%12) =O) C[C@@H] (O) C%10) C (C) C) N=N9) CC7
Molecular Formula
C63H71F2N13O7S
Molecular Weight
1192.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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