MAO-B-IN-45
MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3xTg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.
Product Specifications
CAS Number
3069915-36-9
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction
Smiles
O=C1C (O) =CC=2C=CC (OCC3=CC=C (Cl) C=C3) =CC2N1C
Molecular Formula
C17H14ClNO3
Molecular Weight
315.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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