MXC-017
MXC-017 is an apoptosis inducer capable of crossing the blood-brain barrier, specifically targeting glioma stem cells (GSCs) . It effectively prevents the formation of radiation-induced GSCs while promoting G0/G1 cell cycle arrest and apoptosis. With minimal off-target effects, MXC-017 exhibits no significant cytotoxicity even at concentrations up to 10 μM. Additionally, it significantly extends the median survival in patient-derived orthotopic xenograft (PDOX) glioblastoma (GBM) mouse models when used in conjunction with radiation therapy.
Product Specifications
CAS Number
3037024-97-5
Field of Research
Cell Biology
Smiles
O=C (NCC1=CC=C (C=C1) S (=O) (=O) N2CCCCC2) N3C=CC=4C=CC=CC43
Molecular Formula
C21H23N3O3S
Molecular Weight
397.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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