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KDX1381

KDX1381 is a bivalent CK2α inhibitor with an IC50 of 17 nM and a KD of 54 nM. It demonstrates antitumor activity in murine 786-O and A375 xenograft models. Furthermore, when combined with a vascular endothelial growth factor receptor (VEGFR) inhibitor or DNA-damaging agents, KDX1381 enhances antitumor effects in mouse hepatocellular carcinoma and glioma models.

Product Specifications

CAS Number

2757728-47-3

Field of Research

Metabolism Research, Stem Cell & Developmental Biology

Smiles

O=C (C=1NC=2C=CC (F) =CC2C1C=3N=NN (C3) CC4CCN (CCNS (=O) (=O) C=5C=CC (=CC5) C=6C (F) =CC=CC6O) CC4) C

Molecular Formula

C32H32F2N6O4S

Molecular Weight

634.70

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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