KDX1381
KDX1381 is a bivalent CK2α inhibitor with an IC50 of 17 nM and a KD of 54 nM. It demonstrates antitumor activity in murine 786-O and A375 xenograft models. Furthermore, when combined with a vascular endothelial growth factor receptor (VEGFR) inhibitor or DNA-damaging agents, KDX1381 enhances antitumor effects in mouse hepatocellular carcinoma and glioma models.
Product Specifications
CAS Number
2757728-47-3
Field of Research
Metabolism Research, Stem Cell & Developmental Biology
Smiles
O=C (C=1NC=2C=CC (F) =CC2C1C=3N=NN (C3) CC4CCN (CCNS (=O) (=O) C=5C=CC (=CC5) C=6C (F) =CC=CC6O) CC4) C
Molecular Formula
C32H32F2N6O4S
Molecular Weight
634.70
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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