Zelquistinel

Zelquistinel (AGN-241751) is the orally active N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders[1].

Product Specifications

CAS Number

[2151842-64-5]

Product Name Alternative

AGN-241751; GATE-251

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zelquistinel.html

Concentration

10mM

Purity

99.92

Smiles

CC(C)(C)OC(N1[C@]2(CCC1)C(N(C2)[C@H](C(N)=O)[C@H](O)C)=O)=O

Molecular Formula

C15H25N3O5

Molecular Weight

327.38

References & Citations

[1]Khan, M. Amin, et al.Preparation of spiro-lactams as NMDA receptor modulators and uses thereof.WO2017201283A1|[2]Burgdorf JS, et al., Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects. Int J Neuropsychopharmacol. 2022 Dec 12;25 (12) :979-991.