Zelquistinel
Zelquistinel (AGN-241751) is the orally active N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders[1].
Product Specifications
CAS Number
[2151842-64-5]
Product Name Alternative
AGN-241751; GATE-251
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zelquistinel.html
Concentration
10mM
Purity
99.92
Smiles
CC(C)(C)OC(N1[C@]2(CCC1)C(N(C2)[C@H](C(N)=O)[C@H](O)C)=O)=O
Molecular Formula
C15H25N3O5
Molecular Weight
327.38
References & Citations
[1]Khan, M. Amin, et al.Preparation of spiro-lactams as NMDA receptor modulators and uses thereof.WO2017201283A1|[2]Burgdorf JS, et al., Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects. Int J Neuropsychopharmacol. 2022 Dec 12;25 (12) :979-991.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor
Available Sizes
Curated Selection
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