NCT-502
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1].
Product Specifications
CAS Number
1542213-00-2
Product Name Alternative
NSC51355
UNSPSC
12352005
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nct-502.html
Concentration
10mM
Purity
98.59
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=NC=C(C=C3)C(F)(F)F
Molecular Formula
C18H20F3N5S
Molecular Weight
395.45
References & Citations
[1]Rohde JM, et al. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018 May 1;26 (8) :1727-1739.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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