QC-182
QC-182 is a potent p300/CBP PROTAC degrader. It reduces p300 protein levels in SK-HEP-1 cells with a DC50 of 93 nM. QC-182 effectively inhibits cell growth in SK-HEP-1 and JHH7 cell lines, with IC50 values of 0.733 μM and 0.477 μM, respectively. QC-182 is applicable for hepatocellular carcinoma (HCC) research.
Product Specifications
CAS Number
3032646-96-8
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C1N ([C@H] (C=2N (C=3C (N2) =CC (=CC3) C=4C (C) =NOC4C) C5CCN (CC5) C6CN (C6) C=7C=C8C (=CC7) C (=O) N (C8=O) C9C (=O) NC (=O) CC9) CCC1) C%10=CC (F) =C (F) C=C%10
Molecular Formula
C44H42F2N8O6
Molecular Weight
816.85
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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