DYB-03
DYB-03 is an oral active HIF-1α/EZH2 inhibitor. DYB-03 inhibits migration, invasion, and angiogenesis of lung cancer cells and HUVECs in vitro and in vivo. DYB-03 induces apoptosis in 2-ME2- and GSK126-resistant of A549 and H460 cells[1].
Product Specifications
CAS Number
2982792-85-6
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dyb-03.html
Purity
99.49
Solubility
DMSO : ≥ 100 mg/mL
Smiles
COC1=CC=C(/C=C/C(C2=CC=C(OC(C)(C)C=C3)C3=C2O)=O)C=C1OCCCN4CCOCC4
Molecular Formula
C28H33NO6
Molecular Weight
479.56
References & Citations
[1]Wang J, et al. The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy. Adv Sci (Weinh) . 2024 Feb;11 (7) :e2303904.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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