HTS05585
HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.
Product Specifications
CAS Number
696643-14-8
Field of Research
Immunology & Inflammation
Smiles
N=1OC (=CC1C=2C=CC=CC2) C=3N=C4C=C (C=CN4C3) CC
Molecular Formula
C18H15N3O
Molecular Weight
289.33
Storage Conditions
-20°C
Notes
For research use only.
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