JWJ-01-306
JWJ-01-306 is a molecular glue that targets the C2H2 zinc finger transcription factor ZBTB11. It effectively degrades ZBTB11, reduces oxidative phosphorylation (OXPHOS) and the tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. In mouse models, JWJ-01-306 demonstrates favorable pharmacokinetic properties.
Product Specifications
CAS Number
3069975-17-0
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C1C=C (NC2=CC=CC (=C2) C3 (NCCC4=CC=C (Cl) C (=C4) C (F) (F) F) CCC3) C (=O) N1C5C (=O) NC (=O) CC5
Molecular Formula
C28H26ClF3N4O4
Molecular Weight
574.98
Storage Conditions
-20°C
Notes
For research use only.
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