Nrf2 activator-10
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent antioxidant response element (ARE) inducer, with an EC50 of 2.7 μM, and also acts as an Nrf2 activator. It modifies Keap1, preventing the formation of the Cul3-Keap1 ubiquitin ligase complex, thereby activating Nrf2 transcription. Nrf2 activator-10 provides cellular protection against H2O2-induced apoptosis.
Product Specifications
CAS Number
75483-04-4
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
O=C (OCC) C=1C (=O) N (C=2C=CC=CC2C1Cl) C
Molecular Formula
C13H12ClNO3
Molecular Weight
265.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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