Prexigebersen (sodium)

Prexigebersen sodium is an antisense oligonucleotide designed to inhibit protein synthesis of Grb2 (growth factor receptor bound protein 2) .

Product Specifications

Product Name Alternative

BP1001 (sodium)

UNSPSC

12352208

Target

ERK

Type

Oligonucleotides

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prexigebersen-sodium.html

Purity

95.60

Solubility

H2O : ≥ 100 mg/mL

Smiles

[Prexigebersen(sodium)]

Molecular Formula

C177H206N63Na18O110P17

Molecular Weight

5520.6 (free acid)

References & Citations

[1]Maro Ohanian, Tara L. Lin, Ellen Ritchie, et al. Pierce, Ana Tari Ashizawa, Hagop Kantarjian, Jorge E. Cortes, Gail J. Roboz; Safety and Efficacy of Lower Intensity Induction Therapy with Intravenous Prexigebersen (BP1001) in Patients with High-Risk and Relapsed/Refractory Acute Myeloid Leukemia (AML) . Blood 2021; 138 (Supplement 1) : 1281.|[2]Tremblay G, Khalafaghian G, Legault J, Nielsen P, Bartlett A. Dual ligation hybridization assay for the specific determination of oligonucleotide therapeutics. Bioanalysis. 2011;3 (5) :499-508.