Mifepristone (RU486)
Mifepristone (RU-486) is a potent steroidal antagonist exhibiting subnanomolar affinity for progesterone receptors (PR IC50 = 0.2 nM) and nanomolar activity against glucocorticoid receptors (GR IC50 = 2.6 nM) . This dual-receptor modulator competitively blocks endogenous hormone binding while inducing distinct conformational changes that prevent coactivator recruitment, demonstrating differential antagonism between PR and GR signaling pathways.
Product Specifications
CAS Number
84371-65-3
Field of Research
Pharmacology & Drug Discovery
Purity
>98%
Smiles
C[C@@]12[C@] (O) (C#CC) CC[C@H]1[C@@H]1CCC3=CC (CCC3=C1[C@@H] (C1C=CC (N (C) C) =CC=1) C2) =O
Molecular Formula
C29H35NO2
Molecular Weight
429.593708276749
Notes
For research use only.
Available Sizes
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