4A3-SCC-10
4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. Intravenous administration of LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver.
Product Specifications
Purity
>95%
Smiles
O=C (OCCSSCCOC (C (C) CCSCCCCCCCCCC) =O) CCN (CCCN (C) CCCN (CCC (OCCSSCCOC (C (C) CSCCCCCCCCCC) =O) =O) CCC (OCCSSCCOC (C (C) CSCCCCCCCCCC) =O) =O) CCC (OCCSSCCOC (C (C) CCSCCCCCCCCCC) =O) =O
Molecular Formula
C91H171N3O16S12
Molecular Weight
1948.1
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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