What is the catalog number for 4A3-SCC-10?

The catalog number for 4A3-SCC-10 is orb3033124.

What sizes are available for 4A3-SCC-10?

4A3-SCC-10 is available in the following size(s): 100 mg, 25 mg, 50 mg.

How many pack sizes does 4A3-SCC-10 come in?

4A3-SCC-10 is available in 3 different pack sizes.

Is 4A3-SCC-10 in stock?

4A3-SCC-10 is currently made to order / not held in immediate stock. Contact us for lead time.

4A3-SCC-10

4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. Intravenous administration of LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver.

Product Specifications

Purity

>95%

Smiles

O=C (OCCSSCCOC (C (C) CCSCCCCCCCCCC) =O) CCN (CCCN (C) CCCN (CCC (OCCSSCCOC (C (C) CSCCCCCCCCCC) =O) =O) CCC (OCCSSCCOC (C (C) CSCCCCCCCCCC) =O) =O) CCC (OCCSSCCOC (C (C) CCSCCCCCCCCCC) =O) =O