Lipid 88

Lipid88 is a high-performance, novel ionizable lipid component engineered for advanced mRNA-LNP vaccine delivery. LNP88 formulation demonstrates superior biodistribution, achieving >10-fold higher transfection efficiency in spleen and lymph nodes compared to benchmark lipids like ALC-0315 via intramuscular delivery. When encapsulating antigen-encoding mRNA (e.g., optimized mCSA construct), Lipid-88 based LNPs drive robust humoral and cellular immunity, enabling complete protection against challenging SARS-CoV-2 variants (WA1/2020, Omicron BA.1, BQ.1) in preclinical models. Its design prioritizes potent immunogenicity with favorable safety profiles.

Product Specifications

CAS Number

2982842-99-7

Field of Research

Metabolism Research

Purity

>98%

Smiles

CCCCCCC (CCCC) COC (OCCOC (CCN (CCC (OCCOC (OCC (CCCC) CCCCCC) =O) =O) CCCN (C) CCCN (CCC (OCCOC (OCC (CCCC) CCCCCC) =O) =O) CCC (OCCOC (OCC (CCCC) CCCCCC) =O) =O) =O) =O