Glucocorticoid receptor agonist-2
Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373[1].
Product Specifications
CAS Number
[2166378-92-1]
UNSPSC
12352005
Target
ADC Payload; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glucocorticoid-receptor-agonist-2.html
Purity
97.72
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H][C@]1(C[C@]2(O[C@H](O[C@]23C(CO)=O)C4=CC=C(OC5=CC(N)=CC=C5)C=C4)[H])[C@@]6(C[C@@H](C7=CC(C=C[C@@]7([C@](F)6[C@@H](O)C[C@@]13C)C)=O)F)[H]
Molecular Formula
C34H35F2NO7
Molecular Weight
607.64
References & Citations
[1]Mcpherson MJ, et al. Preparation of glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471. 2017.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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