PD 158771

PD 158771 is an antipsychotic agent that functions as a partial agonist for D2 /D3 receptors (Ki = 42.0/13.7 nM) and as an agonist for 5-HT1A receptors (Ki = 2.6 nM) . PD 158771 can be utilized in antipsychotic research[1].

Product Specifications

CAS Number

[189152-50-9]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pd-158771.html

Smiles

C1(N[C@H]2CC[C@H](CCN3CCN(C4=CC=CC=C4)CC3)CC2)=NC=CC=N1

Molecular Formula

C22H31N5

Molecular Weight

365.52

References & Citations

[1]Akunne HC, et al. PD 158771, a potential antipsychotic agent with D (2) /D (3) partial agonist and 5-HT (1A) agonist actions. I. Neurochemical effects. Neuropharmacology. 2000 Apr 27;39 (7) :1197-210.