2',3'-cGAMP
2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-κB pathway.
Product Specifications
CAS Number
1441190-66-4
Product Name Alternative
Cyclic GMP-AMP, 2'-3'-Cyclic GMP-AMP, 2',3' cGAMP, 2',3'cGAMP, 2',3'-cGAMP, Human Endogenous Metabolite
Field of Research
Immunology & Inflammation, Metabolism Research, Neuroscience
Purity
98.65% (May vary between batches)
Solubility
H2O:≥ 40 mg/mL
Smiles
O[C@H]1[C@@]2 ([C@@H] (O[C@]1 (COP (=O) (O) O[C@@]3 ([C@@] (COP (=O) (O) O2) (O[C@H] ([C@@H]3O) N4C=5C (N=C4) =C (N) N=CN5) [H]) [H]) [H]) N6C7=C (N=C6) C (=O) N=C (N) N7) [H]
Molecular Formula
C20H24N10O13P2
Molecular Weight
674.41
Storage Conditions
-20°C
Notes
For research use only.
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