PROTAC K-Ras Degrader-4
PROTAC K-Ras Degrader-4 (Compound 4) is a proteolysis-targeting chimera (PROTAC) molecule designed to selectively degrade oncogenic mutants of K-Ras, effectively degrading KRASG12D in the GP5d cell line and KRASG12V in SW620 cells with DC50 of 1 nM and 13 nM, respectively; it concomitantly inhibits the downstream MAPK signaling pathway and represents a novel therapeutic strategy for cancer research targeting previously undruggable Ras mutations.
Product Specifications
CAS Number
2938169-99-2
Product Name Alternative
PROTACKRasDegrader4
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.30% (May vary between batches)
Solubility
DMSO:80 mg/mL (80.87 mM)
Smiles
C[C@]1 (C2=C (SC (N) =C2C#N) CCC1) C3=NC (=NO3) C4=NC (=NC=C4) N5[C@@H] (C) CN (CCCCOC=6C=C ([C@H] (C (=O) N7[C@H] (C (NCC8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) C (C) C) ON6) CCC5
Molecular Formula
C50H60N12O6S2
Molecular Weight
989.22
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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